Complex treatment for cervical intraepithelial neoplasia in human papillomavirus persistence: state-of-the-art

Abstract

M.G. Venediktova1, A.N. Sarantsev2, K.V. Morozova1, K.F. Orudzhova1 1Pirogov Russian National Research Medical University, Moscow, Russian Federation 2City Clinical Hospital No. 40, Moscow, Russian Federation The article discusses the results of recent studies on complex treatment for cervical intraepithelial neoplasia (CIN) in women with persistent papillomavirus (HPV). This paper which includes 23 references discusses statistical data on the prevalence of CIN and cervical cancer and describes major mechanisms of pathogenic effects of HPV on cervical epithelium depending on its oncogenic potential. According to the published data, significant immunosuppression of HPV in association with its transforming effect on cell cycle favor precancerous changes. Considering high HPV prevalence (in particular, in women of reproductive age), optimal treatment approach both to fight against HPV persistence outcomes and to increase the chances of eradicating the virus. It was demonstrated that a complex treatment approach which combines destructive techniques and systemic immunotherapy is the most effective one for CIN in HPV persistence. The efficacy of immunomodulatory treatment with Isoprinos ine for HPV was demonstrated. High rate of viral eradication provides minimal risks of LSIL progression as well as regression of dysplasia after 28-day treatment course. Keywords: cervical intraepithelial neoplasia, human papillomavirus, cervical cancer, carcinogenesis, immunomodulatory agent, inosine pranobex, Isoprinosine. For citation: Venediktova M.G., Sarantsev A.N., Morozova K.V., Orudzhova K.F. Complex treatment for cervical intraepithelial neoplasia in human papillomavirus persistence: state-of-the-art. Russian Journal of Woman and Child Health. 2019;2(3):237–242.