Phenalenones from a Marine-Derived Fungus Penicillium Sp.

Abstract

Six new phenalenone derivatives (1–6), along with five known compounds (7–11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.

Keywords

• herqueinones
• phenalenones
• Penicillium sp.
• marine-derived fungi
• adipogenesis
• anti-angiogenesis
• anti-inflammatory