Current Therapeutic Research (Jan 2023)

A Combination of Gamma-Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine, and Cyanocobalamin vs Ginger Extract in the Management of Chronic Motion Sickness: A Clinical Evaluation

  • Carlos P. Nunes, MD,
  • Claudio Rodrigues, MD,
  • Mendel Suchmacher, MD,
  • Claudia Regina Esteves, MD,
  • Karin Gonçalves, PhD,
  • Hélio Rzetelna, MD,
  • Rafael V. Rodrigues, MD,
  • Luciana Regina de Vasconcelos, MD,
  • Spyros G.E. Mezitis, MD, PhD,
  • Heros Rabelo, MSc,
  • Renato Kaufmann, MD, PhD,
  • Fernanda Schwarz, MChem,
  • Henrique Goldberg, (In Memoriam), MD,
  • Aline Sintoveter, MD,
  • Mauro Geller, MD, PhD

Journal volume & issue
Vol. 99
p. 100719

Abstract

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ABSTRACT: Background: Motion sickness (kinetosis) is a common and temporarily incapacitant ailment, manageable with behavioral as well as pharmacological measures. Objective: To assess the effectiveness and safety of a combination of gamma-aminobutyric acid, glutamic acid, calcium, thiamine, pyridoxine, and cyanocobalamin (Group A) (n = 170) and extract of Zingiber officinale (ginger) (Group B) (n = 165) in the management of chronic complaints consistent with motion sickness. Methods: Both groups were tested according to the following end points, under self-paired as well as comparative study designs: reduction of ≥20 score points in the total motion sickness assessment questionnaire (MSAQ) score, percentage of patients presenting a reduction of the total MSAQ score, absolute MSAQ score reduction, physician's assessment scores, final overall assessment of study medication, and willingness to continue treatment. Safety was also evaluated. Results: There was a statistically significant better performance under both study designs for Group A (P = 0.05 using different statistical tests) in all end points. Both regimens were safe, with different neurological and gastrointestinal tolerability outcomes. Conclusions: Group A and Group B regimens were effective and safe in the management of chronic complaints consistent with motion sickness and the Group A regimen was more effective than Group B.

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