Respiratory Research (Dec 2018)

Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma

  • Fajri Gafar,
  • Ilse M. Boudewijn,
  • Claire A. Cox,
  • Judith M. Vonk,
  • Siebrig Schokker,
  • Anne J. Lexmond,
  • Henderik W. Frijlink,
  • Paul Hagedoorn,
  • Dirkje S. Postma,
  • Maarten van den Berge

DOI
https://doi.org/10.1186/s12931-018-0961-2
Journal volume & issue
Vol. 19, no. 1
pp. 1 – 5

Abstract

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Abstract We performed a post-hoc analysis of the OLiVIA-study investigating whether current and ex-smoking asthmatics with small airways dysfunction (SAD) show a better response in airway hyperresponsiveness (AHR) to small particle adenosine after treatment with extrafine compared to non-extrafine particle inhaled corticosteroids (ICS), and to investigate which clinical parameters predict a favorable response to both treatments. We show that smoking and ex-smoking asthmatics with and without SAD have a similar treatment response with either extrafine or non-extrafine particle ICS. We also found that lower blood neutrophils are associated with a smaller ICS-response in smokers and ex-smokers with asthma, independent from the level of blood eosinophils.

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