Autophagy and the Oncogene-induced Senescence

Abstract

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The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here we discuss up-to-date concepts of senescence-related macroautophagy and evaluate the current trend of this growing research field, which has relevance in future perspectives towards therapeutic options against cancer.

Keywords

• Autophagy
• Cancer
• senescence
• oncogene-induced senescence
• tumor suppression mechanisms