Association of metabolic syndrome components with serum lipin-1 level in Gorgan

Abstract

Introduction: Metabolic syndrome (MetS) is increasing healthcare costs worldwide. It has been suggested that serum lipin-1 (LPN1) may be associated with components of MetS. The aim of this study was to evaluate LPN1serum levels and its association with MetS components in subjects with and without MetS in this area. Materials and methods: We included subjects with MetS using the National Cholesterol Education Program, Adult Treatment Panel III criteria. LPN1 levels were measured using the Eliza method. Results: The results showed that waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG) and triglyceride levels were significantly higher and high density lipoprotein cholesterol and LPN1 levels were significantly lower in subjects with MetS compared to subjects without MetS. There was a significant inverse correlation between LPN1 and FBG, SBP, and DBP in MetS patients. In subjects without MetS, there was no correlation between LPN1and MetS components. Conclusion: There appears to be a significant association between some components of MetS and serum LPN1 levels. Further studies are needed to elucidate the underlying mechanisms and possible therapeutic implications of this association for the prevention and treatment of MetS-related disorders.

Keywords

• Metabolic syndrome
• Components
• Lipin-1
• Gorgan