Biomedical and Biotechnology Research Journal (Jan 2022)
Evaluation of antibacterial potential of Syzygium cumini against methicillin-resistant Staphylococcus aureus and macrolide-lincosamide-streptogramin B strains of Staphylococcus aureus and its liquid chromatography mass spectroscopy analysis
Abstract
Background: The resistant strains of Staphylococcus aureus as in form of methicillin-resistant S. aureus (MRSA), inducible clindamycin resistant S. aureus (iMLSB) and constitutive clindamycin-resistant S. aureus (cMLSB) are the major causes of death. An ethnobotanical survey of Syzygium cumini revealed that bioactive compounds showed effective against tested these resistant strains of S. aureus. Methods: The main goal of this study is to screening of phytochemicals by different biochemical tests, antimicrobial evaluation as per agar well-diffusion method and identification of chemical constituents of leaves of Syzygium cumini via liquid chromatography mass spectroscopy (LCMS) technique. Results: The extractive yield was higher with ethanol extract (18.10 ± 0.10). Four phytoconstituents, alkaloids, flavonoids, terpenoids, and tannin found in four solvent extracts except hexane. The zone of inhibition was higher in aqueous extract with ranges 17–27 mm. Twenty different chemical constituents of leaves of aqueous extract of Syzygium cumini were identified through the application of LCMS data. Conclusion: The Syzygium cumini of phytoconstituents showed antibacterial activity against MRSA, iMLSB, and cMLSB. Thus, it may help for the treatment of diseases caused by MRSA, iMLSB, and cMLSB.
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