Plasma levels of vitamin e and carotenoids are decreased in patients with nonalcoholic steatohepatitis (nash)

Abstract

Abstract Objectives Oxidative stress is suggested to play an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). The present study was aimed to compare plasma levels of antioxidants in patients suffering from NASH and healthy controls. Methods Plasma levels of the antioxidants α-tocopherol, γ-tocopherol, lutein, zeaxanthin, β-cryptoxanthin, lycopene, α-carotene β-carotene were determined in 57 patients with biopsy-proven NASH and 40 healthy controls. Results Levels of α-tocopherol (22.4 vs. 26.8 nmol/ ml; p Conclusions Given the decreased levels supplementation of lipophilic antioxidants might be a rational treatment option for patients with NASH.

Keywords

• NASH
• antioxidants
• vitamin A
• vitamin E