Acta Cirúrgica Brasileira (Oct 2015)

Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

  • Marismar Fernandes do Nascimento,
  • Bernadeth Moda de Almeida,
  • John Lennon Silva Cunha,
  • Rafael Barreto Vieira Valois,
  • Juliana Campos Pinheiro,
  • Maria Amália Gonzaga Ribeiro,
  • Sonia Oliveira Lima,
  • Ricardo Luiz Cavalcanti de Albuquerque-Júnior

DOI
https://doi.org/10.1590/S0102-865020150100000002
Journal volume & issue
Vol. 30, no. 10
pp. 660 – 667

Abstract

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PURPOSE: To investigate the effect of low-level laser therapy on bone healing in diabetic rats. METHODS: Bone cavities (19 mm diameter) were performed in the femur of 72 alloxan-induced diabetic rats, which were assigned into four groups: CTR (non-diabetic control), DBT (diabetic) CTRL (non-diabetic irradiated) and DBTL (diabetic irradiated). Low-level laser therapy was performed every 48h for seven days. Animals were euthanized at seven, 18 and 30 days. Alkaline phosphatase serum levels and bone repair were analyzed. RESULTS: Low-level laser therapy significantly increased alkaline phosphatase in at seven and 18 days (p0.05). CONCLUSION: Low-level laser therapy increased the serum levels of alkaline phosphatase and improved bone healing in alloxan-induced diabetic rats.

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