Nature Communications (Mar 2018)

Biosynthesis of fragin is controlled by a novel quorum sensing signal

  • Christian Jenul,
  • Simon Sieber,
  • Christophe Daeppen,
  • Anugraha Mathew,
  • Martina Lardi,
  • Gabriella Pessi,
  • Dominic Hoepfner,
  • Markus Neuburger,
  • Anthony Linden,
  • Karl Gademann,
  • Leo Eberl

DOI
https://doi.org/10.1038/s41467-018-03690-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Fragin is a diazeniumdiolate metabolite with antifungal activity, produced by some bacteria. Here, Jenul et al. show that metal chelation is the molecular basis of fragin’s antifungal activity, and that a gene cluster directing fragin biosynthesis is also involved in the synthesis of a signal molecule.