Nature Communications (Mar 2018)
Biosynthesis of fragin is controlled by a novel quorum sensing signal
Abstract
Fragin is a diazeniumdiolate metabolite with antifungal activity, produced by some bacteria. Here, Jenul et al. show that metal chelation is the molecular basis of fragin’s antifungal activity, and that a gene cluster directing fragin biosynthesis is also involved in the synthesis of a signal molecule.