Nature Communications (Apr 2017)
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
- Alexander Bartelt,
- Clara John,
- Nicola Schaltenberg,
- Jimmy F. P. Berbée,
- Anna Worthmann,
- M. Lisa Cherradi,
- Christian Schlein,
- Julia Piepenburg,
- Mariëtte R. Boon,
- Franz Rinninger,
- Markus Heine,
- Klaus Toedter,
- Andreas Niemeier,
- Stefan K. Nilsson,
- Markus Fischer,
- Sander L. Wijers,
- Wouter van Marken Lichtenbelt,
- Ludger Scheja,
- Patrick C. N. Rensen,
- Joerg Heeren
Affiliations
- Alexander Bartelt
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Clara John
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Nicola Schaltenberg
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Jimmy F. P. Berbée
- Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center
- Anna Worthmann
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- M. Lisa Cherradi
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Christian Schlein
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Julia Piepenburg
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Mariëtte R. Boon
- Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center
- Franz Rinninger
- III. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf
- Markus Heine
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Klaus Toedter
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Andreas Niemeier
- Department of Orthopaedics, University Medical Center Hamburg-Eppendorf
- Stefan K. Nilsson
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Markus Fischer
- Hamburg School of Food Science, Institute of Food Chemistry, University of Hamburg
- Sander L. Wijers
- Department of Human Biology, NUTRIM - School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center
- Wouter van Marken Lichtenbelt
- Department of Human Biology, NUTRIM - School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center
- Ludger Scheja
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- Patrick C. N. Rensen
- Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center
- Joerg Heeren
- Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/ncomms15010
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Activation of brown adipose tissue (BAT) reduces the development of atherosclerosis in animal models. Here the authors show that BAT activation also increases reverse cholesterol transport and turnover of high-density lipoprotein, which likely contributes to the anti-atherosclerotic effect of BAT activation.
