Yolk sac tumor of endometrium: A case report and literature review

Shih-Wen Lin; Shu-Wei Hsieh; Shih-Hung Huang; Hung-Shuo Liang; Chia-Yen Huang

Taiwanese Journal of Obstetrics & Gynecology (Nov 2019)

Yolk sac tumor of endometrium: A case report and literature review

Shih-Wen Lin,
Shu-Wei Hsieh,
Shih-Hung Huang,
Hung-Shuo Liang,
Chia-Yen Huang

Affiliations

Shih-Wen Lin: Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan
Shu-Wei Hsieh: Department of Pathology, Cathay General Hospital, Taipei, Taiwan
Shih-Hung Huang: Department of Pathology, Cathay General Hospital, Taipei, Taiwan
Hung-Shuo Liang: Department of Obstetrics and Gynecology, Sijhih Cathay General Hospital, New Taipei City, Taiwan; Corresponding author. Department of Obstetrics and Gynecology, Sijhih Cathay General Hospital, New Taipei City, Taiwan. Fax: +886 2 8648 2603.
Chia-Yen Huang: Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan; School of Medicine, Fu Jen Catholic University, Hsinchuang, New Taipei City, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; Corresponding author. Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan. Fax: +886 2 8509 6756.

Journal volume & issue: Vol. 58, no. 6
pp. 846 – 848

Abstract

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Objective: To report a rare case of endometrial yolk sac tumor (YST) and review published cases of YST of the endometrium. Case report: A 68-year-old female presented with intermittent vaginal spotting for nine months. An endometrial biopsy showed adenocarcinoma. Complete surgical staging operation was performed and the final pathology revealed stage II endometrial yolk sac tumor. The post-operative α-fetoprotein (AFP) level was 133.4 ng/mL. Post-operative adjuvant chemotherapy with bleomycin, etoposide, and cisplatin (BEP) regimen was prescribed for 6 cycles. AFP levels were normal before the fourth cycle of chemotherapy. She is disease free 6 months after completion of therapy. Conclusion: Primary YSTs arising in the endometrium is an extremely rare disease especially in postmenopausal women. Complete surgical staging operation with adjuvant chemotherapy will lead to good outcome in this disease. Keywords: Yolk sac tumor, Endometrial cancer, Adjuvant chemotherapy

Published in Taiwanese Journal of Obstetrics & Gynecology

ISSN: 1028-4559 (Print)
Publisher: Elsevier
Country of publisher: Taiwan, Province of China
LCC subjects: Medicine: Gynecology and obstetrics
Website: http://www.journals.elsevier.com/taiwanese-journal-of-obstetrics-and-gynecology/

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