Вісник проблем біології і медицини (Dec 2020)
THE ASSESSMENT OF THE INFLUENCE OF THERAPEUTIC AND PREVENTIVE COMPLEX ON PERIODONTIUM AND TISSUE IMMUNITY IN CHILDREN WITH CHRONIC CATARRHAL GINGIVITIS AND PATIENTS WITH GASTRODUODENITIS
Abstract
Chronic catarrhal gingivitis is widespread dental disease in children that can cause periodontitis with subsequent teeth loss.Main topicality of this problem is associated with drugs for treatment and prevention of inflammatory diseases of periodontium in children with chronic gastroduodenitis. The aim is to study the efficacy of the proposed complex of the treatment and prevention of chronic catarrhal gingivitis in children with gastroduodenitis. The object and methods of the investigation. About 500 pupils of secondary schools at the age of 6-12 were examined by us. Examined pupils were divided into 2 groups: the 1st group included somatically healthy children without signs of inflammation of periodontal tissue, 20 somatically healthy children with signs of catarrhal gingivitis and they also contained control group. 20 patients were involved in the main group who had chronic gastroduodenitis and signs of chronic catarrhal gingivitis. These children were in inpatient treatment in gastroenterological department. Before treatment, all children were instructed to follow oral hygiene by brushing and professional cleaning. Children with chronic gastroduodenitis and chronic catarrhal gingivitis obtained the proposed therapeutic and preventive complex. The complex included oral cavity rinsing before the breakfast and during the whole day after meals. After breakfast and in the evening after the last intake of meals, teeth brushing with toothpaste Splat «Medicinal Herbs», mouth rinsing 100 ml of Decasan solution, applications on gums Cholisal (0,5 sm of the gel should be squeezed out on the clean finger and rub in gums during 2 minutes) were recommended. Euro Biotic Zhermina per 1 capsule twice a day after meals is administered internally. This complex included 14 days. Before treatment and in 1,3, 6 months dynamic monitoring by assessment of oral hygiene by indices Silness-Loе and Fedorova-Volodkina, assesmemt of gingivitis severity were performed. Tissue immunity of the oral cavity was evaluated by defining the condition of the balance of pro-and anti-inflammatory IL -1β, IL-10 and the level of IkBα expression before and in one month after therapy. Results of discussion. In month after therapeutic and preventive measures, the condition of gums inflammation improved, index РМА in group of children without somatic disease decreased on 1,7 times, and in group of children with chronic gastoduodenitis or catarrhal gingivitis in 2,1 times and determined mild inflammation. After use of therapeutic and preventive complexes (conventional and proposed by us) in children with chronic catarrhal inflammation of gums somatically without significant signs and against the background of chronic gastroduodenitis one determined the increase of the level of IkBα expression to such one like in healthy children.
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