Nature Communications (May 2021)

Targeting Gα13-integrin interaction ameliorates systemic inflammation

  • Ni Cheng,
  • Yaping Zhang,
  • M. Keegan Delaney,
  • Can Wang,
  • Yanyan Bai,
  • Randal A. Skidgel,
  • Xiaoping Du

DOI
https://doi.org/10.1038/s41467-021-23409-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Bacterial or viral infection can lead to lethal systemic inflammation and thrombosis. Here, the authors show that inhibiting integrin outside-in signaling in leukocytes and platelets alleviates inflammation/clotting and improved survival in septic mice.