Nature Communications (Apr 2018)
Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration
- Akihito Harada,
- Kazumitsu Maehara,
- Yusuke Ono,
- Hiroyuki Taguchi,
- Kiyoshi Yoshioka,
- Yasuo Kitajima,
- Yan Xie,
- Yuko Sato,
- Takeshi Iwasaki,
- Jumpei Nogami,
- Seiji Okada,
- Tetsuro Komatsu,
- Yuichiro Semba,
- Tatsuya Takemoto,
- Hiroshi Kimura,
- Hitoshi Kurumizaka,
- Yasuyuki Ohkawa
Affiliations
- Akihito Harada
- Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
- Kazumitsu Maehara
- Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
- Yusuke Ono
- Graduate School of Biomedical Science, Nagasaki University
- Hiroyuki Taguchi
- Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Research Institute for Science and Engineering, and Institute for Medical-oriented Structural Biology, Waseda University
- Kiyoshi Yoshioka
- Graduate School of Biomedical Science, Nagasaki University
- Yasuo Kitajima
- Graduate School of Biomedical Science, Nagasaki University
- Yan Xie
- Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Research Institute for Science and Engineering, and Institute for Medical-oriented Structural Biology, Waseda University
- Yuko Sato
- Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
- Takeshi Iwasaki
- Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
- Jumpei Nogami
- Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
- Seiji Okada
- Department of Advanced Medical Initiatives, Graduate School of Medical Sciences, Kyushu University
- Tetsuro Komatsu
- Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
- Yuichiro Semba
- Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
- Tatsuya Takemoto
- Institute of Advanced Medical Sciences, Tokushima University
- Hiroshi Kimura
- Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
- Hitoshi Kurumizaka
- Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Research Institute for Science and Engineering, and Institute for Medical-oriented Structural Biology, Waseda University
- Yasuyuki Ohkawa
- Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University
- DOI
- https://doi.org/10.1038/s41467-018-03845-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Incorporation of histone H3 variant H3.3 into chromatin regulates transcription. Here the authors find that H3.3 sub-variant H3mm7 is required for skeletal muscle regeneration and that H3mm7 nucleosomes are unstable and exhibit higher mobility, with H3mm7 promoting open chromatin around promoters.
