Camouflaging bacteria by wrapping with cell membranes

Zhenping Cao; Shanshan Cheng; Xinyue Wang; Yan Pang; Jinyao Liu

doi:10.1038/s41467-019-11390-8

Nature Communications (Aug 2019)

Camouflaging bacteria by wrapping with cell membranes

Zhenping Cao,
Shanshan Cheng,
Xinyue Wang,
Yan Pang,
Jinyao Liu

Affiliations

Zhenping Cao: Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Institute of Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanshan Cheng: Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Institute of Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Xinyue Wang: Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Institute of Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Yan Pang: Department of Ophthalmology, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University
Jinyao Liu: Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Institute of Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s41467-019-11390-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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The use of engineered bacteria for biomedical applications is limited by side effects such as inflammatory response. Here the authors engineer cell membrane coated bacteria as in vivo tumor imaging agents, and show that these generate a lower inflammatory response and reduced macrophage clearance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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