Nature Communications (Mar 2023)
Cryo-EM structure of human heptameric pannexin 2 channel
- Hang Zhang,
- Shiyu Wang,
- Zhenzhen Zhang,
- Mengzhuo Hou,
- Chunyu Du,
- Zhenye Zhao,
- Horst Vogel,
- Zhifang Li,
- Kaige Yan,
- Xiaokang Zhang,
- Jianping Lu,
- Yujie Liang,
- Shuguang Yuan,
- Daping Wang,
- Huawei Zhang
Affiliations
- Hang Zhang
- Department of Biomedical Engineering, Southern University of Science and Technology
- Shiyu Wang
- Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
- Zhenzhen Zhang
- Department of Biomedical Engineering, Southern University of Science and Technology
- Mengzhuo Hou
- Department of Biomedical Engineering, Southern University of Science and Technology
- Chunyu Du
- Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health Center
- Zhenye Zhao
- Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
- Horst Vogel
- Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
- Zhifang Li
- Department of Biomedical Engineering, Southern University of Science and Technology
- Kaige Yan
- School of Life Sciences, Southern University of Science and Technology
- Xiaokang Zhang
- Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
- Jianping Lu
- Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health Center
- Yujie Liang
- Department of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health Center
- Shuguang Yuan
- Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
- Daping Wang
- Department of Biomedical Engineering, Southern University of Science and Technology
- Huawei Zhang
- Department of Biomedical Engineering, Southern University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-023-36861-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
Pannexin 2 plays critical roles in many physiological processes but its mechanism remain unclear. Here, authors report the cryo-EM structure of human Panx2 in the open state and identify critical residues for its gating.
