Enhanced antibacterial activity of chitosan, guar gum and polyvinyl alcohol blend matrix loaded with amoxicillin and doxycycline hyclate drugs

Abstract

This study focusses on the synthesis of a series of semisynthetic polymeric blended membranes based on chitosan, guar gum and polyvinyl alcohol for the sustained delivery of antibacterial drugs'' with ''A series of semisynthetic polymeric blended membranes based on GG (guar gum), CS (chitosan) and PVA (polyvinyl alcohol) was fabricated for the sustained delivery of antibacterial drugs. The drug employed in this study includes amoxicillin and doxycycline hyclate. Different ratios of chitosan CS and GG were blended with constant ratio of PVA to synthesize membranes using solution casting method. Fourier transforms infrared (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD) study showed the blend formation, surface morphology and crystalline nature of polymeric membranes respectively. Successful bonding among the ingredients was confirmed by crystalline peak of CS cellulose at 22.6˚. Swelling test was used to analyze the water absorbing capacity of the membranes, indicating the hydrophilic nature, making these membranes more liable for drug release application. Results revealed that 25 mg was the ideal amount of drug loaded on blended membrane. Antimicrobial activity was promising against selected bacterial strains and cytotoxicity assay showed that the polymeric membranes have great potential for biomedical field. The membrane (B-2) was considered best amongst all based on the composition and ratio 3:1 of CS to GG, demonstrated good binding between constituents. These membranes can be employed for sustainable drug delivery process due to good swelling, antimicrobial and absorption characteristics.

Keywords

• Chitosan
• Guar Gum
• Polyvinyl alcohol
• Solution casting method
• Drug loading