Frontiers in Oncology (Oct 2021)
A Forgotten Corner in Cancer Immunotherapy: The Role of Lipids
- Yang Yu,
- Yang Yu,
- Yang Yu,
- Lei Gao,
- Lei Gao,
- Lei Gao,
- Yunpeng Wang,
- Yunpeng Wang,
- Yunpeng Wang,
- Bo Xu,
- Bo Xu,
- Bo Xu,
- Ewetse Paul Maswikiti,
- Ewetse Paul Maswikiti,
- Ewetse Paul Maswikiti,
- Haiyuan Li,
- Haiyuan Li,
- Haiyuan Li,
- Peng Zheng,
- Peng Zheng,
- Peng Zheng,
- Pengxian Tao,
- Pengxian Tao,
- Pengxian Tao,
- Lin Xiang,
- Lin Xiang,
- Lin Xiang,
- Baohong Gu,
- Baohong Gu,
- Baohong Gu,
- Alexandra Lucas,
- Hao Chen,
- Hao Chen,
- Hao Chen
Affiliations
- Yang Yu
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Yang Yu
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Yang Yu
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- Lei Gao
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Lei Gao
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Lei Gao
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- Yunpeng Wang
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Yunpeng Wang
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Yunpeng Wang
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- Bo Xu
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Bo Xu
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Bo Xu
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- Ewetse Paul Maswikiti
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Ewetse Paul Maswikiti
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Ewetse Paul Maswikiti
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- Haiyuan Li
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Haiyuan Li
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Haiyuan Li
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- Peng Zheng
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Peng Zheng
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Peng Zheng
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- Pengxian Tao
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Pengxian Tao
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Pengxian Tao
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- Lin Xiang
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Lin Xiang
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Lin Xiang
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- Baohong Gu
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Baohong Gu
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Baohong Gu
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- Alexandra Lucas
- Center for Personalized Diagnostics and Center for Immunotherapy, Vaccines and Virotherapy, The Biodesign Institute, Arizona State University, Tempe, AZ, United States
- Hao Chen
- Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, China
- Hao Chen
- The Second Clinical Medical College, Lanzhou University, Lanzhou, China
- Hao Chen
- Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
- DOI
- https://doi.org/10.3389/fonc.2021.751086
- Journal volume & issue
-
Vol. 11
Abstract
In the past decade, cancer immunotherapy has achieved great success owing to the unravelling of unknown molecular forces in cancer immunity. However, it is critical that we address the limitations of current immunotherapy, including immune-related adverse events and drug resistance, and further enhance current immunotherapy. Lipids are reported to play important roles in modulating immune responses in cancer. Cancer cells use lipids to support their aggressive behaviour and allow immune evasion. Metabolic reprogramming of cancer cells destroys the equilibrium between lipid anabolism and catabolism, resulting in lipid accumulation within the tumour microenvironment (TME). Consequently, ubiquitous lipids, mainly fatty acids, within the TME can impact the function and phenotype of infiltrating immune cells. Determining the complex roles of lipids and their interactions with the TME will provide new insight for improving anti-tumour immune responses by targeting lipids. Herein, we present a review of recent literature that has demonstrated how lipid metabolism reprogramming occurs in cancer cells and influences cancer immunity. We also summarise the potential for lipid-based clinical translation to modify immune treatment.
Keywords
