Терапевтический архив (Sep 2012)
Risk of cardiovascular death in relation to blood lipid composition in male inhabitants of Tyumen: results of a 12-year prospective study
Abstract
Aim. To evaluate the impact of the blood levels of lipoproteins, such as total cholesterol (TC), high-density lipoproteins (HDL), triglycerides (TG), on the risk for cardiovascular death in an open Tyumen male population on the basis of a 12-year prospective follow-up study. Subjects and methods. Standard methods were used to conduct an epidemiological study of a representative sample of Tyumen males aged 25-64 years in 1996. The cardiological screening response rate was 79.5% (n=795). Eighty-five cardiovascular deaths (CVD) were registered in the male cohort during 12 years of the prospective follow-up study. The Cox proportional hazard regression model was employed to assess the relative risk (RR) of CVD. Survival rates were analyzed with the Kaplan-Meier method; the significance of lifespan differences in two groups was estimated using the log-rank test. Results. In the male cohort, a statistically significant increase in the RR of CVD occurred, starting with a TC level of ≥230 mg/dl. The lowest survival rates were noted in the males with hypercholesterolemia (HC). The statistically significant increase in the RR of CVD depending on the levels of TG was found in its 5th quintile (138 mg/dl or more). Lower survival rates were stated in the males with hypertriglyceridemia (HTG) than in those with normal blood TG levels. There were neither statistically significant results in the assessment of RR and survival rates in relation to the level of low-density lipoprotein cholesterol, no data on the effect of the level of HDL cholesterol on the RR of CVD in the males. Conclusion. According to the data of a 12-year cohort study, the open Tyumen male population was found to have a high RR of CVD in those who had TC levels ≥230 mg/dl and TG levels ≥138 mg/dl, which determined the lowest survival rates in males with HC and HTG.
