Journal of Applied Pharmaceutical Research (Sep 2014)

Formulation and evaluation of colon targeted dosage form of prednisolone tablet using sterculia gum

  • Neha Singh Raghuvanshi,
  • Laxmi Goswami,
  • Preeti Kothiyal

Journal volume & issue
Vol. 2, no. 3
pp. 16 – 19

Abstract

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Matrix tablets of Prednisolone were prepared by wet granulation method using various proportions of Sterculia gum with Carbopol 934P and Sterculia gum with Ethyl cellulose at 1:1, 1: .5 and 1:2 ratio. Coating was carried out by using 1:1 ratio of Eudragit L100 and Eudragit S100. All the preparation were evaluated for Pre compressional properties, Post compressional properties and in-vitro Dissolution study in different pH buffer of 0.1N HCL ,pH 7.4 , pH 6.8 in order to mimic GIT condition. Formulation shows good results with good percentage yield.

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