Медицинский вестник Юга России (Mar 2015)

INJECTING DRUG USE AS A FACTOR CONTRIBUTES TO HIV-INFECTION

  • Е. P. Stanko,
  • S. A. Lyalikov,
  • S. A. Igumnov,
  • V. M. Cyrkunov,
  • N. V. Matievskya

DOI
https://doi.org/10.21886/2219-8075-2015-1-86-90
Journal volume & issue
Vol. 0, no. 1
pp. 86 – 90

Abstract

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Purpose: to determine the nature of the impact of injecting drug use on cellular immunity and assessment of the importance of drug use as a factor contributing to HIV infection and aff ect the course of disease in HIV- positive patients.Materials and methods: surveyed 144 people - 109 patients with drug addiction, HIV infection and HIV - positive injecting drug users and 35 healthy individuals.Results: found that injecting drug potentiates caused by HIV infection decrease the percentage of helper cells ( CD4 + lymphocytes ), natural killer T (CD3 +16 +56 + lymphocytes), natural killer cells (CD3- 16 +56 + cells ), increased cytotoxic T lymphocytes (CD8 + lymphocytes), the proportion and absolute number of T- lymphocyte activation characteristics (CD3 + HLA-DR + cells).Summary: injecting drug use increases the risk of infection among injecting drug users (IDUs) without HIV, and decreases the antiviral response in HIV- positive patients, a statistically signifi cant potentiating caused by HIV in the blood decrease in helper cells, and natural killer T- natural, regulatory cells, immune hyperactivation that contributes to the progression of the disease.

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