Residual Change of Four Pesticides in the Processing of <i>Pogostemon cablin</i> and Associated Factors
Yuanxi Liu,
Zuntao Zheng,
Hongbin Liu,
Dongjun Hou,
Hailiang Li,
Yaolei Li,
Wenguang Jing,
Hongyu Jin,
Ying Wang,
Shuangcheng Ma
Affiliations
Yuanxi Liu
Institute for Control of Chinese Traditional Medicine and Ethnic Medicine (ICCTMEM), National Institutes for Food and Drug Control (NIFDC), Beijing 100050, China
Zuntao Zheng
Institute for the Control of Agrochemicals, Ministry of Agriculture and Rural Affairs, Beijing 100125, China
Hongbin Liu
China Animal Disease Control Center, Ministry of Agriculture and Rural Affairs, Beijing 102629, China
Dongjun Hou
China Animal Disease Control Center, Ministry of Agriculture and Rural Affairs, Beijing 102629, China
Hailiang Li
Institute for Control of Chinese Traditional Medicine and Ethnic Medicine (ICCTMEM), National Institutes for Food and Drug Control (NIFDC), Beijing 100050, China
Yaolei Li
Institute for Control of Chinese Traditional Medicine and Ethnic Medicine (ICCTMEM), National Institutes for Food and Drug Control (NIFDC), Beijing 100050, China
Wenguang Jing
Institute for Control of Chinese Traditional Medicine and Ethnic Medicine (ICCTMEM), National Institutes for Food and Drug Control (NIFDC), Beijing 100050, China
Hongyu Jin
Institute for Control of Chinese Traditional Medicine and Ethnic Medicine (ICCTMEM), National Institutes for Food and Drug Control (NIFDC), Beijing 100050, China
Ying Wang
Institute for Control of Chinese Traditional Medicine and Ethnic Medicine (ICCTMEM), National Institutes for Food and Drug Control (NIFDC), Beijing 100050, China
Shuangcheng Ma
Institute for Control of Chinese Traditional Medicine and Ethnic Medicine (ICCTMEM), National Institutes for Food and Drug Control (NIFDC), Beijing 100050, China
Before use as medicines, most traditional Chinese medicine (TCM) plants are processed and decocted. During processing, there may be some changes in pesticide residues in TCM. In recent years, reports have studied the changes of pesticides during the processes of boiling, drying and peeling of TCM materials but have rarely involved special processing methods for TCM, such as ethanol extraction and volatile oil extraction. The changes of carbendazim, carbofuran, pyridaben and tebuconazole residues in common processing methods for P. cablin products were systemically assessed in this study. After each processing step, the pesticides were quantitated by UPLC-MS/MS. The results showed amount decreases in various pesticides to different extents after each processing procedure. Processing factor (PF) values for the four pesticides after decoction, 75% ethanol extraction and volatile oil extraction were 0.02~0.75, 0.40~0.98 and 0~0.02, respectively, which indicated that residual pesticide concentrations may depend on the processing technique. A risk assessment according to the hazard quotient with PF values showed that residual pesticide amounts in P. cablin were substantially lower than levels potentially posing a health risk. Overall, these findings provide insights into the safety assessment of P. cablin.
