Immunological imprinting of the antibody response in COVID-19 patients

Teresa Aydillo; Alexander Rombauts; Daniel Stadlbauer; Sadaf Aslam; Gabriela Abelenda-Alonso; Alba Escalera; Fatima Amanat; Kaijun Jiang; Florian Krammer; Jordi Carratala; Adolfo García-Sastre

doi:10.1038/s41467-021-23977-1

Nature Communications (Jun 2021)

Immunological imprinting of the antibody response in COVID-19 patients

Teresa Aydillo,
Alexander Rombauts,
Daniel Stadlbauer,
Sadaf Aslam,
Gabriela Abelenda-Alonso,
Alba Escalera,
Fatima Amanat,
Kaijun Jiang,
Florian Krammer,
Jordi Carratala,
Adolfo García-Sastre

Affiliations

Teresa Aydillo: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Alexander Rombauts: Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L’Hospitalet de Llobregat
Daniel Stadlbauer: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Sadaf Aslam: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Gabriela Abelenda-Alonso: Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L’Hospitalet de Llobregat
Alba Escalera: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Fatima Amanat: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Kaijun Jiang: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Florian Krammer: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Jordi Carratala: Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, L’Hospitalet de Llobregat
Adolfo García-Sastre: Department of Microbiology, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-021-23977-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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In addition to SARS-CoV-2, other coronaviruses also infect human, but whether consecutive infections cross-modulate the induced immune response is still unclear. Here the authors show that SARS-CoV-2 infection boosts pre-existing responses to other coronaviruses, yet such back-boosting hampers the induction of specific antibodies against SARS-CoV-2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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