Nature Communications (Oct 2020)

AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

  • Catherine D. Yao,
  • Daniel Haensel,
  • Sadhana Gaddam,
  • Tiffany Patel,
  • Scott X. Atwood,
  • Kavita Y. Sarin,
  • Ramon J. Whitson,
  • Siegen McKellar,
  • Gautam Shankar,
  • Sumaira Aasi,
  • Kerri Rieger,
  • Anthony E. Oro

DOI
https://doi.org/10.1038/s41467-020-18762-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Basal cell carcinoma (BCC) cells with increased nuclear myocardin-related transcription factor (nMRTF) levels are resistant to Smoothened inhibitors, however how MRTF activity is regulated is still elusive. Here, the authors identify a LYPD3+/TACSTD2+/LY6D+ BCC subpopulation of resistant BCC cells where AP-1 and TGFß drive nMRTF activation and amplify noncanonical Gli1 activity