Journal of Personalized Medicine (Aug 2022)
Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis
- Sandrine Morel,
- Isabel C. Hostettler,
- Georg R. Spinner,
- Romain Bourcier,
- Joanna Pera,
- Torstein R. Meling,
- Varinder S. Alg,
- Henry Houlden,
- Mark K. Bakker,
- Femke van’t Hof,
- Gabriel J. E. Rinkel,
- Tatiana Foroud,
- Dongbing Lai,
- Charles J. Moomaw,
- Bradford B. Worrall,
- Jildaz Caroff,
- Pacôme Constant-dits-Beaufils,
- Matilde Karakachoff,
- Antoine Rimbert,
- Aymeric Rouchaud,
- Emilia I. Gaal-Paavola,
- Hanna Kaukovalta,
- Riku Kivisaari,
- Aki Laakso,
- Behnam Rezai Jahromi,
- Riikka Tulamo,
- Christoph M. Friedrich,
- Jerome Dauvillier,
- Sven Hirsch,
- Nathalie Isidor,
- Zolt Kulcsàr,
- Karl O. Lövblad,
- Olivier Martin,
- Paolo Machi,
- Vitor Mendes Pereira,
- Daniel Rüfenacht,
- Karl Schaller,
- Sabine Schilling,
- Agnieszka Slowik,
- Juha E. Jaaskelainen,
- Mikael von und zu Fraunberg,
- Jordi Jiménez-Conde,
- Elisa Cuadrado-Godia,
- Carolina Soriano-Tárraga,
- Iona Y. Millwood,
- Robin G. Walters,
- The @neurIST project,
- The ICAN Study Group,
- Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study Investigators,
- International Stroke Genetics Consortium (ISGC),
- Helen Kim,
- Richard Redon,
- Nerissa U. Ko,
- Guy A. Rouleau,
- Antti Lindgren,
- Mika Niemelä,
- Hubert Desal,
- Daniel Woo,
- Joseph P. Broderick,
- David J. Werring,
- Ynte M. Ruigrok,
- Philippe Bijlenga
Affiliations
- Sandrine Morel
- Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
- Isabel C. Hostettler
- Stroke Research Centre, University College London Queen Square Institute of Neurology, London WC1N 3BG, UK
- Georg R. Spinner
- ZHAW School of Life Sciences and Facility Management, 8820 Wädenswil, Switzerland
- Romain Bourcier
- Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), University Hospital Centre Nantes, University of Nantes, L’institut Du Thorax, 44007 Nantes, France
- Joanna Pera
- Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, ul. Botaniczna 3, 31-503 Krakow, Poland
- Torstein R. Meling
- Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
- Varinder S. Alg
- Stroke Research Centre, University College London Queen Square Institute of Neurology, London WC1N 3BG, UK
- Henry Houlden
- Neurogenetics Laboratory, The National Hospital of Neurology and Neurosurgery, London WC1N 3BG, UK
- Mark K. Bakker
- Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CS Utrecht, The Netherlands
- Femke van’t Hof
- Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CS Utrecht, The Netherlands
- Gabriel J. E. Rinkel
- Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CS Utrecht, The Netherlands
- Tatiana Foroud
- Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
- Dongbing Lai
- Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
- Charles J. Moomaw
- Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
- Bradford B. Worrall
- Departments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22903, USA
- Jildaz Caroff
- Department of Interventional Neuroradiology—NEURI Brain Vascular Center, Bicêtre Hospital, APHP, 94270 Le Kremlin Bicêtre, France
- Pacôme Constant-dits-Beaufils
- Institut national de la santé et de la recherche médicale (INSERM), CIC 1413, Clinique des Données, University Hospital Centre Nantes, 44000 Nantes, France
- Matilde Karakachoff
- Institut national de la santé et de la recherche médicale (INSERM), CIC 1413, Clinique des Données, University Hospital Centre Nantes, 44000 Nantes, France
- Antoine Rimbert
- Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), University Hospital Centre Nantes, University of Nantes, L’institut Du Thorax, 44007 Nantes, France
- Aymeric Rouchaud
- Department of Neuroradiology, Dupuytren University Hospital, 87000 Limoges, France
- Emilia I. Gaal-Paavola
- Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland
- Hanna Kaukovalta
- Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland
- Riku Kivisaari
- Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland
- Aki Laakso
- Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland
- Behnam Rezai Jahromi
- Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland
- Riikka Tulamo
- Neurosurgery Research Group, Biomedicum, 00290 Helsinki, Finland
- Christoph M. Friedrich
- Department of Computer Science, University of Applied Science and Arts, 44139 Dortmund, Germany
- Jerome Dauvillier
- SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
- Sven Hirsch
- ZHAW School of Life Sciences and Facility Management, 8820 Wädenswil, Switzerland
- Nathalie Isidor
- Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
- Zolt Kulcsàr
- Diagnostic and Interventional, Department of Diagnostics, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
- Karl O. Lövblad
- Diagnostic and Interventional, Department of Diagnostics, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
- Olivier Martin
- SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
- Paolo Machi
- Diagnostic and Interventional, Department of Diagnostics, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
- Vitor Mendes Pereira
- Division of Neurosurgery, Department of Surgery, St Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
- Daniel Rüfenacht
- Swiss Neuroradiology Institute, 8002 Zurich, Switzerland
- Karl Schaller
- Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
- Sabine Schilling
- ZHAW School of Life Sciences and Facility Management, 8820 Wädenswil, Switzerland
- Agnieszka Slowik
- Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, ul. Botaniczna 3, 31-503 Krakow, Poland
- Juha E. Jaaskelainen
- Neurosurgery NeuroCenter Kuopio, University Hospital Kuopio, 70210 Kuopio, Finland
- Mikael von und zu Fraunberg
- Neurosurgery NeuroCenter Kuopio, University Hospital Kuopio, 70210 Kuopio, Finland
- Jordi Jiménez-Conde
- Institut Hospital del Mar d’Investigacions Biomèdiques (IMIM) and Hospital del Mar, 08003 Barcelona, Spain
- Elisa Cuadrado-Godia
- Institut Hospital del Mar d’Investigacions Biomèdiques (IMIM) and Hospital del Mar, 08003 Barcelona, Spain
- Carolina Soriano-Tárraga
- Institut Hospital del Mar d’Investigacions Biomèdiques (IMIM) and Hospital del Mar, 08003 Barcelona, Spain
- Iona Y. Millwood
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX1 2JD, UK
- Robin G. Walters
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX1 2JD, UK
- The @neurIST project
- The ICAN Study Group
- Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study Investigators
- International Stroke Genetics Consortium (ISGC)
- Helen Kim
- Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94143, USA
- Richard Redon
- Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), University Hospital Centre Nantes, University of Nantes, L’institut Du Thorax, 44007 Nantes, France
- Nerissa U. Ko
- Department of Neurology, University of California, San Francisco, CA 94143, USA
- Guy A. Rouleau
- Montreal Neurological Institute and Hospital, McGill University, Montréal, QC H3A 0G4, Canada
- Antti Lindgren
- Neurosurgery NeuroCenter Kuopio, University Hospital Kuopio, 70210 Kuopio, Finland
- Mika Niemelä
- Department of Neurosurgery, Helsinki University Hospital, University of Helsinki, 00260 Helsinki, Finland
- Hubert Desal
- Department of Neuroradiology, University Hospital of Nantes, 44000 Nantes, France
- Daniel Woo
- Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
- Joseph P. Broderick
- Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
- David J. Werring
- Stroke Research Centre, University College London Queen Square Institute of Neurology, London WC1N 3BG, UK
- Ynte M. Ruigrok
- Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, 3584 CS Utrecht, The Netherlands
- Philippe Bijlenga
- Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
- DOI
- https://doi.org/10.3390/jpm12091410
- Journal volume & issue
-
Vol. 12,
no. 9
p. 1410
Abstract
Intracranial aneurysms (IAs) are usually asymptomatic with a low risk of rupture, but consequences of aneurysmal subarachnoid hemorrhage (aSAH) are severe. Identifying IAs at risk of rupture has important clinical and socio-economic consequences. The goal of this study was to assess the effect of patient and IA characteristics on the likelihood of IA being diagnosed incidentally versus ruptured. Patients were recruited at 21 international centers. Seven phenotypic patient characteristics and three IA characteristics were recorded. The analyzed cohort included 7992 patients. Multivariate analysis demonstrated that: (1) IA location is the strongest factor associated with IA rupture status at diagnosis; (2) Risk factor awareness (hypertension, smoking) increases the likelihood of being diagnosed with unruptured IA; (3) Patients with ruptured IAs in high-risk locations tend to be older, and their IAs are smaller; (4) Smokers with ruptured IAs tend to be younger, and their IAs are larger; (5) Female patients with ruptured IAs tend to be older, and their IAs are smaller; (6) IA size and age at rupture correlate. The assessment of associations regarding patient and IA characteristics with IA rupture allows us to refine IA disease models and provide data to develop risk instruments for clinicians to support personalized decision-making.
Keywords
