Nature Communications (Jun 2020)

Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells

  • Hao Li,
  • Iannis E. Adamopoulos,
  • Vaishali R. Moulton,
  • Isaac E. Stillman,
  • Zach Herbert,
  • James J. Moon,
  • Amir Sharabi,
  • Suzanne Krishfield,
  • Maria G. Tsokos,
  • George C. Tsokos

DOI
https://doi.org/10.1038/s41467-020-16636-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Splenic marginal zone macrophages can establish immune tolerance and limit the development of systemic lupus erythematosus (SLE). Here the authors show that these cells do this by clearing apoptotic cells, and defects in these cells result in the generation of self-reactive double negative T cells that are known to contribute to SLE pathogenesis.