Changes in levels of Interleukin-6 (IL-6) and Interleukin-8 (IL-8) in the Serum of Preterm Delivery Pregnant Women Affected by Gingivitis

Abstract

Background: Periodontal disease increases local and systemic inflammatory responses in pregnant women, which may lead to premature delivery. Objectives: To detect maternal serum levels of proinflammatory cytokine (Interleukine-6, Interleukin-8) with preterm delivery in pregnant women suffering from gingivitis. Cases and methods: In this case-control study, a total of 85 pregnant women, were included in the study, of whom 55 had gingivitis: 25 preterm deliveries and 30 full-term deliveries. Thirty healthy pregnant women with healthy gingiva were in the control group. They were selected from Al-Ramadi Teaching Hospital for Gynecology and Pediatrics, from November 2022 to May 2023. Blood samples were collected from all participants and the biomarkers cytokines were detected by immunosorbent assay ( ) kits. Results: The current study showed an increased level of interleukin-6 and interleukin-8 in the pre-term delivery gingivitis group followed by full-term-delivery pregnant groups having gingivitis compared with the control group, with statistically highly significant differences ( ). Conclusion: Pregnant women with gingivitis with the highest levels of Interlukine-6 and Interlukine-8 were more prone to have premature delivery than those with lower levels of Interleukins and those without gingivitis. Received: June, 2023 Accepted: Aug, 2023 Published: Jan..2024

Keywords

• Gingivitis
• Periodontal disease
• preterm delivery
• full term-delivery
• Interleukine-6
• Interleukin-8