Communications Biology (May 2021)
Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation
- Maria Feola,
- Andrea Zamperone,
- Daniel Moskop,
- Huiyong Chen,
- Carla Casu,
- Dechen Lama,
- Julie Di Martino,
- Mansour Djedaini,
- Luena Papa,
- Marc Ruiz Martinez,
- Tenzin Choesang,
- Jose Javier Bravo-Cordero,
- Matthew MacKay,
- Paul Zumbo,
- Nathan Brinkman,
- Charles S. Abrams,
- Stefano Rivella,
- Shilpa Hattangadi,
- Christopher E. Mason,
- Ronald Hoffman,
- Peng Ji,
- Antonia Follenzi,
- Yelena Z. Ginzburg
Affiliations
- Maria Feola
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Andrea Zamperone
- Perlmutter Cancer Center, New York University Langone Medical Center
- Daniel Moskop
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Huiyong Chen
- Erythropoiesis Laboratory, New York Blood Center
- Carla Casu
- Children’s Hospital of Philadelphia
- Dechen Lama
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Julie Di Martino
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Mansour Djedaini
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Luena Papa
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Marc Ruiz Martinez
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Tenzin Choesang
- Erythropoiesis Laboratory, New York Blood Center
- Jose Javier Bravo-Cordero
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Matthew MacKay
- Weill Cornell Medical College
- Paul Zumbo
- Weill Cornell Medical College
- Nathan Brinkman
- CSL Behring
- Charles S. Abrams
- Perelman Center for Advanced Medicine, University of Pennsylvania School of Medicine
- Stefano Rivella
- Children’s Hospital of Philadelphia
- Shilpa Hattangadi
- Yale University
- Christopher E. Mason
- Weill Cornell Medical College
- Ronald Hoffman
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Peng Ji
- Northwestern University
- Antonia Follenzi
- University of Piemonte Orientale, Amedeo Avogadro
- Yelena Z. Ginzburg
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s42003-021-02046-9
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 14
Abstract
Maria Feola et al., elucidate the compensatory role of pleckstrin-2 in ineffective erythropoiesis in β-thalassemic mice by reducing cofilin-mediated apoptosis and enhancing enucleation by activating RacGTPases. These findings could support future therapeutic interventions.
