Infection and Drug Resistance (Aug 2024)
Microbial Etiology, Antimicrobial Resistance, and Risk Factors of Surgical Site Infections in Gestational Diabetes Mellitus Patients Undergoing Elective Pre-Labor Cesarean Deliveries
Abstract
Caixia Liang,1,2 Yanping Lu,1,2 Xiajie Luo,1,2 Fengchai Weng1,2 1Department of Geriatrics, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang Province, 318050, People’s Republic of China; 2Department of Geriatric Rehabilitation, Taizhou Rehabilitation Hospital, Taizhou, Zhejiang Province, 318050, People’s Republic of ChinaCorrespondence: Yanping Lu, Department of Geriatrics, Taizhou Hospital of Zhejiang Province, 150 Ximen Street, Linhai City, Taizhou, Zhejiang Province, 318001, People’s Republic of China, Email [email protected]: Gestational Diabetes Mellitus (GDM) significantly increases the risk of adverse pregnancy outcomes, including elective pre-labor cesarean deliveries. Postoperative surgical site infections (SSIs) pose a significant concern, underscoring the need for a detailed investigation into their causes and preventative measures. The aim of this study is to systematically identify and analyze the microbial etiology and antimicrobial resistance profiles of pathogens responsible for SSIs in GDM patients undergoing elective pre-labor cesarean deliveries. Additionally, this research aims to elucidate the risk factors contributing to SSIs, with a specific focus on operation duration, amniotic fluid contamination, and genital tract inflammation, and their correlation with the incidence of SSIs.Methods: A retrospective analysis was conducted at our Hospital between September 2018 and July 2023, involving 150 GDM patients who underwent elective pre-labor cesarean deliveries. Patients were categorized into infected and uninfected groups based on postoperative SSIs. Clinical data were meticulously collected and analyzed using SPSS software (version 27.0). Independent sample t-tests and chi-square tests were employed for statistical analysis.Results: Microbial profiling revealed that Gram-negative bacteria, primarily E. coli, constituted approximately 59.46% of the isolated strains, exhibiting significant resistance to commonly used antibiotics such as ampicillin and cefotaxime. Elevated levels of biomarkers, including Procalcitonin (PCT) and Hemoglobin A1c (HbA1c), were significantly associated with SSIs. Multivariate logistic regression analysis identified operation time ≥ 1-hour, amniotic fluid contamination, and genital tract inflammation as significant risk factors.Conclusion: This study highlights the microbial etiology, resistance patterns, and risk factors for SSIs in GDM cesarean patients, emphasizing the need for tailored preoperative evaluations.Keywords: gestational diabetes mellitus, surgical site infections, elective pre-labor cesarean delivery, risk factors, microbial etiology
