Frontiers in Veterinary Science (Sep 2024)
Whole-genome sequencing identified candidate genes associated with high and low litter size in Chuanzhong black goats
- Conghui Guo,
- Conghui Guo,
- Conghui Guo,
- Junning Ye,
- Junning Ye,
- Junning Ye,
- Jie Liu,
- Jie Liu,
- Jie Liu,
- Zhihan Li,
- Zhihan Li,
- Zhihan Li,
- Ming Deng,
- Ming Deng,
- Ming Deng,
- Yongqing Guo,
- Yongqing Guo,
- Yongqing Guo,
- Guangbin Liu,
- Guangbin Liu,
- Guangbin Liu,
- Baoli Sun,
- Baoli Sun,
- Baoli Sun,
- Yaokun Li,
- Yaokun Li,
- Yaokun Li,
- Dewu Liu,
- Dewu Liu,
- Dewu Liu
Affiliations
- Conghui Guo
- Herbivore Laboratory, College of Animal Science, South China Agricultural University, Guangzhou, China
- Conghui Guo
- Guangdong Gene Bank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, China
- Conghui Guo
- Guangdong Key Laboratory of Agricultural Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, China
- Junning Ye
- Herbivore Laboratory, College of Animal Science, South China Agricultural University, Guangzhou, China
- Junning Ye
- Guangdong Gene Bank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, China
- Junning Ye
- Guangdong Key Laboratory of Agricultural Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, China
- Jie Liu
- Herbivore Laboratory, College of Animal Science, South China Agricultural University, Guangzhou, China
- Jie Liu
- Guangdong Gene Bank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, China
- Jie Liu
- Guangdong Key Laboratory of Agricultural Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, China
- Zhihan Li
- Herbivore Laboratory, College of Animal Science, South China Agricultural University, Guangzhou, China
- Zhihan Li
- Guangdong Gene Bank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, China
- Zhihan Li
- Guangdong Key Laboratory of Agricultural Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, China
- Ming Deng
- Herbivore Laboratory, College of Animal Science, South China Agricultural University, Guangzhou, China
- Ming Deng
- Guangdong Gene Bank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, China
- Ming Deng
- Guangdong Key Laboratory of Agricultural Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, China
- Yongqing Guo
- Herbivore Laboratory, College of Animal Science, South China Agricultural University, Guangzhou, China
- Yongqing Guo
- Guangdong Gene Bank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, China
- Yongqing Guo
- Guangdong Key Laboratory of Agricultural Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, China
- Guangbin Liu
- Herbivore Laboratory, College of Animal Science, South China Agricultural University, Guangzhou, China
- Guangbin Liu
- Guangdong Gene Bank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, China
- Guangbin Liu
- Guangdong Key Laboratory of Agricultural Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, China
- Baoli Sun
- Herbivore Laboratory, College of Animal Science, South China Agricultural University, Guangzhou, China
- Baoli Sun
- Guangdong Gene Bank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, China
- Baoli Sun
- Guangdong Key Laboratory of Agricultural Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, China
- Yaokun Li
- Herbivore Laboratory, College of Animal Science, South China Agricultural University, Guangzhou, China
- Yaokun Li
- Guangdong Gene Bank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, China
- Yaokun Li
- Guangdong Key Laboratory of Agricultural Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, China
- Dewu Liu
- Herbivore Laboratory, College of Animal Science, South China Agricultural University, Guangzhou, China
- Dewu Liu
- Guangdong Gene Bank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou, China
- Dewu Liu
- Guangdong Key Laboratory of Agricultural Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou, China
- DOI
- https://doi.org/10.3389/fvets.2024.1420164
- Journal volume & issue
-
Vol. 11
Abstract
The reproductive performance of goats significantly influences breeding efficiency and economic returns, with litter size serving as a comprehensive indicator. Despite this, research on the genetic control of litter size remains limited. Therefore, we aimed to explore the candidate genes affecting fecundity and compared the whole-genome sequences (WGS) of 15 high-litter (HL) and 15 low-litter (LL) size in Chuanzhong black goats. Then genetic diversity and genomic variation patterns were analyzed by phylogenetic, principal component and population genetic structure analysis, it was found that HL and LL subpopulations diverged. Population evolutionary selection elimination analysis was performed by Fst and θπ resulted in 506 genes were annotated in HL and 528 genes in LL. These genes were mainly related to Hippo signaling pathway, G protein-coupled signaling pathway, G protein-coupled receptor activity, cell surface receptor signaling pathway, gonadal and reproductive structure development. According to the significantly selected genomic regions and important pathways, we found that the g.89172108T > G variant locus in the exon of the AMH gene was significantly associated with litter size (P < 0.05), which could be used as an auxiliary selection gene for the high fertility of Chuanzhong black Goat.
Keywords