Frontiers in Allergy (Mar 2024)

Case Report: Mast cell anergy: absence of symptoms after accidental re-exposure to amoxicillin/clavulanic acid 3 days after anaphylaxis

  • Loris Guyénard,
  • Loris Guyénard,
  • Marie Tauber,
  • Marie Tauber,
  • Sophie Debord-Peguet,
  • Sophie Debord-Peguet,
  • Frédéric Berard,
  • Frédéric Berard,
  • Audrey Nosbaum,
  • Audrey Nosbaum,
  • Florence Hacard,
  • Florence Hacard,
  • Mariana Castells,
  • Jean-François Nicolas,
  • Jean-François Nicolas

DOI
https://doi.org/10.3389/falgy.2024.1366922
Journal volume & issue
Vol. 5

Abstract

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Empty mast cell syndrome, also named post anaphylaxis mast cell anergy (PAMA), is a temporary state of loss of mast cell responsiveness after a severe immediate hypersensitivity reaction. In this study, we describe a case of PAMA after accidental re-exposure to amoxicillin in a patient who developed severe anaphylaxis to this drug three days earlier in the operating room. To our knowledge, this report is the second to document this phenomenon.

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