Проблемы особо опасных инфекций (Aug 2012)

Qualitative Indicators of Microbial Cells of Yersinia pestis EV Strain Depending on Their Morphological Traits in Different Temperature Conditions of Manufacturing of Plague Vaccine Preparation

  • D. A. Budyka,
  • A. I. Bondarenko,
  • A. A. Fisun,
  • N. V. Abzaeva,
  • G. F. Ivanova,
  • S. E. Gostishcheva,
  • S. M. Rudnev

DOI
https://doi.org/10.21055/0370-1069-2012-4-33-35
Journal volume & issue
Vol. 0, no. 4(114)
pp. 33 – 35

Abstract

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The preference of the (21±1) °C temperature for cultivation of the vaccine strain Yersinia pestis EV in the live plague vaccine biomass production to (27±1) °C is experimentally confirmed. An original interpretation of the mechanism of small cells stability that are formed at (21±1) °C has been proposed. This interpretation stipulates a smaller damaging effect of steam molecules during sublimation in the process of lyophilization.

Keywords