IL-6-Producing, Noncatecholamines Secreting Pheochromocytoma Presenting as Fever of Unknown Origin

Marco Ciacciarelli; Davide Bellini; Andrea Laghi; Alessandro Polidoro; Antonio Pacelli; Anna Giulia Bottaccioli; Giuseppina Palmaccio; Federica Stefanelli; Piera Clemenzi; Luisa Carini; Luigi Iuliano; Cesare Alessandri

doi:10.1155/2016/3489046

Case Reports in Medicine (Jan 2016)

IL-6-Producing, Noncatecholamines Secreting Pheochromocytoma Presenting as Fever of Unknown Origin

Marco Ciacciarelli,
Davide Bellini,
Andrea Laghi,
Alessandro Polidoro,
Antonio Pacelli,
Anna Giulia Bottaccioli,
Giuseppina Palmaccio,
Federica Stefanelli,
Piera Clemenzi,
Luisa Carini,
Luigi Iuliano,
Cesare Alessandri

Affiliations

Marco Ciacciarelli: Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Davide Bellini: Department of Radiological Sciences, Oncology and Pathology, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Andrea Laghi: Department of Radiological Sciences, Oncology and Pathology, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Alessandro Polidoro: Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Antonio Pacelli: Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Anna Giulia Bottaccioli: Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Giuseppina Palmaccio: Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Federica Stefanelli: Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Piera Clemenzi: Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Luisa Carini: Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Luigi Iuliano: Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy
Cesare Alessandri: Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 34, 04100 Latina, Italy

DOI: https://doi.org/10.1155/2016/3489046
Journal volume & issue: Vol. 2016

Abstract

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Fever of unknown origin (FUO) can be an unusual first clinical manifestation of pheochromocytoma. Pheochromocytomas are tumors that may produce a variety of substances in addition to catecholamines. To date, several cases of IL-6-producing pheochromocytomas have been reported. This report describes a 45-year-old woman with pheochromocytoma who was admitted with FUO, normal blood pressure levels, microcytic and hypochromic anemia, thrombocytosis, hyperfibrinogenemia, hypoalbuminemia, and normal levels of urine and plasma metanephrines. After adrenalectomy, fever and all inflammatory findings disappeared.

Published in Case Reports in Medicine

ISSN: 1687-9627 (Print); 1687-9635 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://onlinelibrary.wiley.com/journal/1683

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