Intensive Therapy of Patients with Acetic Acid Poisoning Complicated by Shock

Abstract

Objective: to evaluate the efficiency of the elaborated intensive therapy policy for acute acetic acid poisoning complicated by exotoxic shock.Subjects and methods. The results of treatment were analyzed in 72 patients admitted in 2008—2012 with severe acute acetic acid poisoning complicated by exotoxic shock. The patients were divided into 2 groups: 1) combination therapy added by an improved intensive therapy complex; 2) conventional therapy. All the patients underwent comprehensive clinical and laboratory examination.Results and discussion. Group 1 versus the study group showed 1.7-, 2.0-, and 2.4- fold increases in the reduction of free hemoglobin levels 12, 24, and 48 hours after applying the improved complex of intensive therapy, respectively. In Group 1, hemodynamic and acidbase balance parameters recovered much faster and the incidence of acute renal failure and mortality rates were 2.1 and 2.0 times lower than those in the comparison group.Conclusion. Incorporation of the agents that correct volemic disorders and improve microcirculation into intensive therapy for acute acetic acid poisoning can considerably reduce the time of shock emergence, prevent acute renal failure, and decrease mortality rates.

Keywords

• acetic acid, exotoxic shock, combination therapy, 6% hydroxyethyl starch solution, rheosorbilact, succinic acid, hemodynamic parameters, acid-base balance