Nature Communications (Jan 2017)
K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression
- Zhenyue Hao,
- Yi Sheng,
- Gordon S. Duncan,
- Wanda Y. Li,
- Carmen Dominguez,
- Jennifer Sylvester,
- Yu-Wen Su,
- Gloria H.Y. Lin,
- Bryan E. Snow,
- Dirk Brenner,
- Annick You-Ten,
- Jillian Haight,
- Satoshi Inoue,
- Andrew Wakeham,
- Alisha Elford,
- Sara Hamilton,
- Yi Liang,
- Juan C. Zúñiga-Pflücker,
- Housheng Hansen He,
- Pamela S. Ohashi,
- Tak W. Mak
Affiliations
- Zhenyue Hao
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Yi Sheng
- Department of Biology, York University
- Gordon S. Duncan
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Wanda Y. Li
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Carmen Dominguez
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Jennifer Sylvester
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Yu-Wen Su
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Gloria H.Y. Lin
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Bryan E. Snow
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Dirk Brenner
- Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health
- Annick You-Ten
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Jillian Haight
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Satoshi Inoue
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Andrew Wakeham
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Alisha Elford
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Sara Hamilton
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Yi Liang
- Princess Margaret Cancer Centre, University Health Network
- Juan C. Zúñiga-Pflücker
- Department of Immunology, University of Toronto
- Housheng Hansen He
- Princess Margaret Cancer Centre, University Health Network
- Pamela S. Ohashi
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- Tak W. Mak
- The Campbell Family Institute for Breast Cancer Research, University Health Network
- DOI
- https://doi.org/10.1038/ncomms14003
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
The E3 ligase Mule has been previously reported to be essential for B cell development and function by modulating p53 ubiquitination and degradation. Here Haoet al. identify KLF4 as a novel ubiquitination target of Mule and show it controls T cell proliferation and autoimmunity.
