Cancer Medicine (May 2023)

Symptomatic benefit of momelotinib in patients with myelofibrosis: Results from the SIMPLIFY phase III studies

  • Ruben A. Mesa,
  • Stacie Hudgens,
  • Lysbeth Floden,
  • Claire N. Harrison,
  • Jeanne Palmer,
  • Vikas Gupta,
  • Donal P. McLornan,
  • Mary F. McMullin,
  • Jean‐Jaques Kiladjian,
  • Lynda Foltz,
  • Uwe Platzbecker,
  • M. Laura Fox,
  • Adam J. Mead,
  • David M. Ross,
  • Stephen T. Oh,
  • Andrew Perkins,
  • Michael F. Leahy,
  • Samineh Deheshi,
  • Rafe Donahue,
  • Barbara J. Klencke,
  • Srdan Verstovsek

DOI
https://doi.org/10.1002/cam4.5799
Journal volume & issue
Vol. 12, no. 9
pp. 10612 – 10624

Abstract

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Abstract Background Myelofibrosis (MF)‐associated constitutional symptoms can severely impact health‐related quality of life. Clinical trials in MF traditionally measure symptom response to treatment as a landmark endpoint of total symptom score (TSS) reduction ≥50% from baseline. However, this dichotomous assessment provides a limited view of clinically relevant symptomatic changes. Herein we evaluated longitudinal change from baseline in TSS over the continuous 24‐week period and individual symptom scores to obtain a more comprehensive understanding of symptom benefits experienced by patients with MF receiving therapy. Methods Longitudinal symptom change was evaluated using mixed‐effect model repeated measure (MMRM) methodology with individual item‐level analyses to complement the interpretation of the landmark symptom results in the completed phase III SIMPLIFY studies of momelotinib in MF. MMRM compared mean change in TSS from baseline with Week 24 using data from all patient visits. Generalized estimating equations were used to estimate item‐level odds ratios using multiple predictive imputations for missing data. Results Momelotinib and ruxolitinib groups reported similar overall symptom improvements, with a TSS difference of <1.5 points between groups for each post‐baseline visit in SIMPLIFY‐1. In SIMPLIFY‐2, the improvement in TSS observed in momelotinib‐treated patients was consistent with that observed in SIMPLIFY‐1, whereas progressive TSS deterioration was observed with control. Item‐level scores were heterogeneous in both studies. A similar and greater proportion of momelotinib‐treated patients were categorized as “improved” or “stable” compared with control in SIMPLIFY‐1 and SIMPLIFY‐2, respectively. Odds ratios for between‐group comparison ranged from 0.75 to 1.21 in SIMPLIFY‐1, demonstrating similarity in likelihood of symptom improvement. In SIMPLIFY‐2, the likelihood of symptom improvement in each item was higher in the momelotinib arm. Conclusions These findings suggest that momelotinib provides clinically relevant symptom benefits in the JAK inhibitor‐naïve and JAK inhibitor‐exposed settings.

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