Cytotoxic Compounds Isolated from Murraya tetramera Huang
Chun-Xue You,
Kai Yang,
Cheng-Fang Wang,
Wen-Juan Zhang,
Ying Wang,
Jiao Han,
Li Fan,
Shu-Shan Du,
Zhu-Feng Geng,
Zhi-Wei Deng
Affiliations
Chun-Xue You
State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China
Kai Yang
State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China
Cheng-Fang Wang
State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China
Wen-Juan Zhang
State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China
Ying Wang
State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China
Jiao Han
Analytical and Testing Center, Beijing Normal University, Haidian District, Beijing 100875, China
Li Fan
China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Xicheng District, Beijing 100088, China
Shu-Shan Du
State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Haidian District, Beijing 100875, China
Zhu-Feng Geng
Analytical and Testing Center, Beijing Normal University, Haidian District, Beijing 100875, China
Zhi-Wei Deng
Analytical and Testing Center, Beijing Normal University, Haidian District, Beijing 100875, China
A new compound and seven known compounds were isolated from Murraya tetramera Huang for the first time, and they were identified with NMR and MS spectral analysis. It was confirmed that the new compound was 10-methoxy-7-methyl-2H-benzo[g]chromen-2-one (3) and the others were β-eudesmol (1), trans-3β-(1-hydroxy-1-methylethyl)-8aβ-methyl-5-methylenedecalin-2-one (2), 5,7-dimethoxy-8-[(Z)-3'-methyl-butan-1',3'-dienyl]coumarin (4), 7-geranyloxy-6-methoxycoumarin (5), 5,7-dimethoxy-8-(3-methyl-2-oxo-butyl)coumarin (6), murrangatin acetate (7) and toddalenone (8). Furthermore, the cytotoxic activity against human lung adenocarcinoma (A549), human hepatocellular carcinoma cells (SMMC-7721), human bladder tumor cells (EJ), human cervical carcinoma cells (HeLa), and human B-lineage acute lymphoblastic leukemia 1 cells (BALL-1) was evaluated for all compounds. It was found that five of them displayed various degrees of cytotoxicity against different testing targets. Compound 1 showed significant cytotoxic activity against the five cell lines (A549, SMMC-7721, EJ, Hela and BALL-1). Compounds 2 and 5 showed significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1). Compound 4 showed significant cytotoxicity against three cell lines (A549, EJ and BALL-1). However, compound 3 only showed fair cytotoxicity against the BALL-1 cell line. The structure-active relationships were investigated as well. These active compounds might be potential lead compounds for the treatment of cancer.
