From Synthesis to Clinical Trial: Novel Bioinductive Calcium Deficient HA/β-TCP Bone Grafting Nanomaterial
Oleg Mishchenko,
Anna Yanovska,
Oksana Sulaieva,
Roman Moskalenko,
Mykola Pernakov,
Yevheniia Husak,
Viktoriia Korniienko,
Volodymyr Deineka,
Oleksii Kosinov,
Olga Varakuta,
Simonas Ramanavicius,
Suren Varzhapetjan,
Almira Ramanaviciene,
Dzanna Krumina,
Gundega Knipše,
Arunas Ramanavicius,
Maksym Pogorielov
Affiliations
Oleg Mishchenko
Department of Surgical And Propaedeutic Dentistry, Zaporizhzhia State Medical and Pharmaceutical University, 26, Prosp. Mayakovskogo, 69035 Zaporizhzhia, Ukraine
Anna Yanovska
Theoretical and Applied Chemistry Department, Sumy State University, R-Korsakova Street, 40007 Sumy, Ukraine
Oksana Sulaieva
Medical Laboratory CSD, Vasylkivska Street, 45, 21000 Kyiv, Ukraine
Roman Moskalenko
Ukrainian-Swedish Centre SUMEYA, Sumy State University, R-Korsakova Street, 40007 Sumy, Ukraine
Mykola Pernakov
Department of Morphology, Sumy State University, R-Korsakova Street, 40007 Sumy, Ukraine
Yevheniia Husak
Biomedical Research Centre, Sumy State University, R-Korsakova Street, 40007 Sumy, Ukraine
Viktoriia Korniienko
Biomedical Research Centre, Sumy State University, R-Korsakova Street, 40007 Sumy, Ukraine
Volodymyr Deineka
Biomedical Research Centre, Sumy State University, R-Korsakova Street, 40007 Sumy, Ukraine
Oleksii Kosinov
Department of Surgical And Propaedeutic Dentistry, Zaporizhzhia State Medical and Pharmaceutical University, 26, Prosp. Mayakovskogo, 69035 Zaporizhzhia, Ukraine
Olga Varakuta
Department of Surgical And Propaedeutic Dentistry, Zaporizhzhia State Medical and Pharmaceutical University, 26, Prosp. Mayakovskogo, 69035 Zaporizhzhia, Ukraine
Simonas Ramanavicius
Department of Electrochemical Material Science, State Research Institute Center for Physical Sciences and Technology (FTMC), Sauletekio Av. 3, LT-10257 Vilnius, Lithuania
Suren Varzhapetjan
Department of Surgical And Propaedeutic Dentistry, Zaporizhzhia State Medical and Pharmaceutical University, 26, Prosp. Mayakovskogo, 69035 Zaporizhzhia, Ukraine
Almira Ramanaviciene
NanoTechnas-Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania
Dzanna Krumina
Faculty of Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia
Gundega Knipše
Faculty of Medicine, University of Latvia, Jelgavas iela 3, LV-1004 Riga, Latvia
Arunas Ramanavicius
NanoTechnas-Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania
Maksym Pogorielov
Biomedical Research Centre, Sumy State University, R-Korsakova Street, 40007 Sumy, Ukraine
Maxillary sinus augmentation is a commonly used procedure for the placement of dental implants. However, the use of natural and synthetic materials in this procedure has resulted in postoperative complications ranging from 12% to 38%. To address this issue, we developed a novel calcium deficient HA/β-TCP bone grafting nanomaterial using a two-step synthesis method with appropriate structural and chemical parameters for sinus lifting applications. We demonstrated that our nanomaterial exhibits high biocompatibility, enhances cell proliferation, and stimulates collagen expression. Furthermore, the degradation of β-TCP in our nanomaterial promotes blood clot formation, which supports cell aggregation and new bone growth. In a clinical trial involving eight cases, we observed the formation of compact bone tissue 8 months after the operation, allowing for the successful installation of dental implants without any early postoperative complications. Our results suggest that our novel bone grafting nanomaterial has the potential to improve the success rate of maxillary sinus augmentation procedures.
