Low plasma vitamin D is associated with increased 28-day mortality and worse clinical outcomes in critically ill patients
Fatemeh Sistanian,
Alireza Sedaghat,
Mohaddeseh Badpeyma,
Majid Khadem Rezaiyan,
Ahmad Bagheri Moghaddam,
Golnaz Ranjbar,
Mostafa Arabi,
Mohammad Bagherniya,
Abdolreza Norouzy
Affiliations
Fatemeh Sistanian
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences
Alireza Sedaghat
Department of Anesthesiology, Faculty of Medicine, Lung Diseases Research Center, Mashhad University of Medical Science
Mohaddeseh Badpeyma
Student Research Committee, Tabriz University of Medical Sciences
Majid Khadem Rezaiyan
Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences
Ahmad Bagheri Moghaddam
Department of Anesthesiology, Faculty of Medicine, Lung Diseases Research Center, Mashhad University of Medical Science
Golnaz Ranjbar
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences
Mostafa Arabi
Department of Basic Sciences, School of Medicine, Neyshabur University of Medical Sciences
Mohammad Bagherniya
Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences
Abdolreza Norouzy
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences
Abstract Background & objective Patients in the intensive care unit have a high prevalence of vitamin D deficiency (VDD). In the present study, clinical outcomes in the ICU were analyzed with vitamin D status. Materials and methods In this prospective, multicenter study, sampling was conducted on seven ICUs in three hospitals. Within the first 24 h of ICU admission, patient’s serum vitamin D levels were measured, and their disease severity was monitored using the scores of acute physiologic assessment and chronic health evaluation II (APACHE II), sequential organ failure assessment (SOFA), and the modified Nutrition Risk in Critically ill (mNUTRIC) score. Results A total of 236 patients were enrolled in this study, of which 163 (69.1%) had lower vitamin D levels than 20 ng/ml upon ICU admission. The patients with VDD had higher APACHE II scores)P = 0.02), SOFA scores (P 30 ng/ml) had a shorter stay at ICU (P < 0.001). VDD was independently associated with 28-day mortality (OR: 4.83; 95% CI: 1.63–14.27; P = 0.004). Conclusion The data showed that VDD was common among the critically ill and was related to a more severe course of illness and a higher mortality rate.
