Cancer Management and Research (Nov 2020)
Overexpression of MTFR2 Predicts Poor Prognosis of Breast Cancer
Abstract
Wenjie Lu,1,* Rukun Zang,1,* Yuanna Du,1 Xinghua Li,1 Hongwei Li,1 Chuan Liu,2 Yipeng Song,1 Yuncheng Li,3,* Yang Wang1 1Department of Radiation Oncology, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University, Yantai, Shandong, People’s Republic of China; 2Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yipeng Song; Yang WangDepartment of Radiation Oncology, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University, 20 Yuhuangdi East Road, Yantai, Shandong 264000, People’s Republic of ChinaTel +8613361328765; +8615318695096Email [email protected]; [email protected]: Mitochondrial fission regulator 2 (MTFR2) has been reported to promote proliferation, migration and invasion in tumors; however, little is known about its function in breast cancer. Thus, we investigated the effect of MTFR2 expression on prognosis of breast cancer.Methods: The expression of MTFR2 in breast cancer tissues was detected by immunohistochemistry, and overall survival (OS) and recurrence free survival (RFS) were evaluated by the Log rank test and Cox model.Results: We found that MTFR2 expression was significantly associated with clinical stage (P< 0.001), T classification (P=0.005), N classification (P=0.001), M classification (P=0.041), HER2 expression (P= 0.001), and molecular subtypes (P=0.002), respectively. Compared with low MTFR2 expression, the patients with higher expression of MTFR2 exhibited significantly shorter OS and RFS (All P < 0.001). Both univariate and multivariate analyses showed that MTFR2 was an independent prognostic factor for OS (HR, 2.8, 95% CI 1.1– 6.8, P = 0.023) and RFS (HR, 2.8, 95% CI 1.2– 6.4, P = 0.015) in breast cancer patients. Moreover, in HER2 positive and TNBC subtype, the associations between high MTFR2 expression and poor OS and RFS were more pronounced.Conclusion: Taken together, our results demonstrated that high MTFR2 expression was associated with poor prognosis of breast cancer patients, and such an association was more pronounced in the patients with aggressive tumors. Therefore, MTFR2 expression might be a potentially important prognostic biomarker and clinical target for patients with breast cancer.Keywords: MTFR2, breast neoplasms, prognosis, biomarker, survival analysis
