Nature Communications (Oct 2017)
NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
- Jianrong Wang,
- Nanhai He,
- Na Zhang,
- Dexian Quan,
- Shuo Zhang,
- Caroline Zhang,
- Ruth T. Yu,
- Annette R. Atkins,
- Ruihong Zhu,
- Chunhui Yang,
- Ying Cui,
- Christopher Liddle,
- Michael Downes,
- Hui Xiao,
- Ye Zheng,
- Johan Auwerx,
- Ronald M. Evans,
- Qibin Leng
Affiliations
- Jianrong Wang
- CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Nanhai He
- Gene Expression Laboratory, Salk Institute for Biological Studies
- Na Zhang
- CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Dexian Quan
- CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Shuo Zhang
- CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Caroline Zhang
- Gene Expression Laboratory, Salk Institute for Biological Studies
- Ruth T. Yu
- Gene Expression Laboratory, Salk Institute for Biological Studies
- Annette R. Atkins
- Gene Expression Laboratory, Salk Institute for Biological Studies
- Ruihong Zhu
- CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Chunhui Yang
- CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Ying Cui
- CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Christopher Liddle
- Storr Liver Centre, Westmead Millennium Institute, Sydney Medical School, University of Sydney
- Michael Downes
- Gene Expression Laboratory, Salk Institute for Biological Studies
- Hui Xiao
- CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- Ye Zheng
- Immunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies
- Johan Auwerx
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne
- Ronald M. Evans
- Gene Expression Laboratory, Salk Institute for Biological Studies
- Qibin Leng
- CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-017-00931-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Thymocytes are screened by two processes, termed positive and negative selections, which are permissive only for immature thymocytes with intermediate avidity to the selecting ligands. Here the authors show that the nuclear receptor NCoR1 suppresses Bim1 to inhibit negative selection and promote thymocyte survival.
