Recent Progress on Rapid Lateral Flow Assay-Based Early Diagnosis of COVID-19

Ying Zhang; Ying Zhang; Yujuan Chai; Zulu Hu; Zhourui Xu; Meirong Li; Xin Chen; Chengbin Yang; Jia Liu

doi:10.3389/fbioe.2022.866368

Frontiers in Bioengineering and Biotechnology (May 2022)

Recent Progress on Rapid Lateral Flow Assay-Based Early Diagnosis of COVID-19

Ying Zhang,
Ying Zhang,
Yujuan Chai,
Zulu Hu,
Zhourui Xu,
Meirong Li,
Xin Chen,
Chengbin Yang,
Jia Liu

Affiliations

Ying Zhang: Central Laboratory, Longgang District People’s Hospital of Shenzhen and The Second Affiliated Hospital of the Chinese University of Hong Kong, Shenzhen, China
Ying Zhang: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China
Yujuan Chai: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China
Zulu Hu: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China
Zhourui Xu: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China
Meirong Li: Central Laboratory, Longgang District People’s Hospital of Shenzhen and The Second Affiliated Hospital of the Chinese University of Hong Kong, Shenzhen, China
Xin Chen: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China
Chengbin Yang: Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China
Jia Liu: Central Laboratory, Longgang District People’s Hospital of Shenzhen and The Second Affiliated Hospital of the Chinese University of Hong Kong, Shenzhen, China

DOI: https://doi.org/10.3389/fbioe.2022.866368
Journal volume & issue: Vol. 10

Abstract

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The outbreak of the coronavirus disease 2019 (COVID-19) has resulted in enormous losses worldwide. Through effective control measures and vaccination, prevention and curbing have proven significantly effective; however, the disease has still not been eliminated. Therefore, it is necessary to develop a simple, convenient, and rapid detection strategy for controlling disease recurrence and transmission. Taking advantage of their low-cost and simple operation, point-of-care test (POCT) kits for COVID-19 based on the lateral flow assay (LFA) chemistry have become one of the most convenient and widely used screening tools for pathogens in hospitals and at home. In this review, we introduce essential features of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, compare existing detection methods, and focus on the principles, merits and limitations of the LFAs based on viral nucleic acids, antigens, and corresponding antibodies. A systematic comparison was realized through summarization and analyses, providing a comprehensive demonstration of the LFA technology and insights into preventing and curbing the COVID-19 pandemic.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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