Nature Communications (Dec 2018)
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease
- Vaibhav B. Patel,
- Pavel Zhabyeyev,
- Xueyi Chen,
- Faqi Wang,
- Manish Paul,
- Dong Fan,
- Brent A. McLean,
- Ratnadeep Basu,
- Pu Zhang,
- Saumya Shah,
- John F. Dawson,
- W. Glen Pyle,
- Mousumi Hazra,
- Zamaneh Kassiri,
- Saugata Hazra,
- Bart Vanhaesebroeck,
- Christopher A. McCulloch,
- Gavin Y. Oudit
Affiliations
- Vaibhav B. Patel
- Division of Cardiology, Department of Medicine
- Pavel Zhabyeyev
- Division of Cardiology, Department of Medicine
- Xueyi Chen
- Division of Cardiology, Department of Medicine
- Faqi Wang
- Division of Cardiology, Department of Medicine
- Manish Paul
- Department of Biotechnology, North Orissa University
- Dong Fan
- Mazankowski Alberta Heart Institute, University of Alberta
- Brent A. McLean
- Mazankowski Alberta Heart Institute, University of Alberta
- Ratnadeep Basu
- Mazankowski Alberta Heart Institute, University of Alberta
- Pu Zhang
- Mazankowski Alberta Heart Institute, University of Alberta
- Saumya Shah
- Division of Cardiology, Department of Medicine
- John F. Dawson
- Department of Molecular and Cellular Biology, University of Guelph
- W. Glen Pyle
- Centre of Cardiovascular Investigations, University of Guelph
- Mousumi Hazra
- Department of Botany and Microbiology, Gurukula Kangri University
- Zamaneh Kassiri
- Mazankowski Alberta Heart Institute, University of Alberta
- Saugata Hazra
- Department of Biotechnology, Indian Institute of Technology
- Bart Vanhaesebroeck
- UCL Cancer Institute, University College London, London
- Christopher A. McCulloch
- Matrix Dynamics Group, Faculty of Dentistry, University of Toronto
- Gavin Y. Oudit
- Division of Cardiology, Department of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-07812-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Gelsolin is an actin severing and capping protein that regulates cytoskeletal remodeling. Here the authors show that gelsolin is negatively regulated in the heart by PI3Kα‐ generated PIP3, and that loss of gelsolin activity prevents adverse cytoskeletal remodeling and heart failure.
