Frontiers in Cardiovascular Medicine (May 2023)

Atherosclerotic cardiovascular diseases in inflammatory bowel diseases: to the heart of the issue

  • Roberto Gabbiadini,
  • Arianna Dal Buono,
  • Elisabetta Mastrorocco,
  • Elisabetta Mastrorocco,
  • Virginia Solitano,
  • Virginia Solitano,
  • Alessandro Repici,
  • Alessandro Repici,
  • Antonino Spinelli,
  • Antonino Spinelli,
  • Gianluigi Condorelli,
  • Gianluigi Condorelli,
  • Alessandro Armuzzi,
  • Alessandro Armuzzi

DOI
https://doi.org/10.3389/fcvm.2023.1143293
Journal volume & issue
Vol. 10

Abstract

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Atherosclerotic cardiovascular disease and stroke are the leading causes of morbidity and mortality worldwide. Along to the traditional risk factors for these diseases, chronic inflammation is known to be an important player in accelerating the process of atherosclerosis, which can result in an increased incidence of arterial thromboembolic events. As in other chronic inflammatory diseases, in the past few years, several studies suggested that subjects affected by inflammatory bowel diseases (IBD) may also be at an incremented risk of atherosclerotic disease, especially during the periods of disease's flare. Therefore, IBD treatment may assume an important role for achieving both disease remission and the control of the atherosclerotic risk. In this article we aimed to perform a comprehensive review on evidence on the increased risk of arterial thromboembolic events in patients affected by IBD and discuss the potential role of IBD therapy in reducing this risk.

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