Lipid level and risk of Alzheimer′s disease: a systematic review and meta-analysis

Xuan-rui LÜ; Jing XU; Xiao-nan LIN; Jing SONG

doi:10.11847/zgggws1138716

Zhongguo gonggong weisheng (Aug 2022)

Lipid level and risk of Alzheimer′s disease: a systematic review and meta-analysis

Xuan-rui LÜ,
Jing XU,
Xiao-nan LIN,
,
,
,
Jing SONG,
,
,

Affiliations

Xuan-rui LÜ: Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, China
Jing XU: Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, China
Xiao-nan LIN: Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, China
: Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, China
: Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, China
: Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, China
Jing SONG: Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, China
: Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, China
: Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, China
: Research Group of Jian Gong on Pharmacoepidemiology and Clinical Drug Evaluation, Shenyang Pharmaceutical University, Shenyang, Liaoning Province 110016, China

DOI: https://doi.org/10.11847/zgggws1138716
Journal volume & issue: Vol. 38, no. 8
pp. 1066 – 1069

Abstract

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ObjectiveTo systematically evaluate the role of blood lipid level in predicting the risk of Alzheimer′s disease (AD). MethodsWe searched Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database for Chinese Technical Periodicals (VIP), Pubmed, Web of Science, Springer, and Cocharne Library for literatures on the correlation between AD incidence and blood lipid level published in Chinese or English till June 2021 and supplementary manual tracing for some of the references was also conducted. Newcastle-Ottawa-Scale literature quality evaluation scale was adopted to evaluate the quality of the included studies. Statistical analyses were performed with RevMan5.3 software. ResultsA total of 15 eligible studies were selected according to the inclusion and exclusion criteria, and the data on blood lipid level were collected from 1 435 healthy elderly people and 2 162 elderly people with AD. Meta-analysis showed that there was no significant difference in total cholesterol (TC) and triglyceride (TG) level between the AD sufferers and the healthy controls；low-density lipoprotein cholesterol (LDL-C) was significantly higher in the AD sufferers than that in the healthy controls (mean difference [MD] = 3.59，95% confidence interval [95% CI]: 0.98 – 6.21); while, high-density lipoprotein cholesterol (HDL-C) was significantly lower in the AD sufferers than that in the healthy controls (MD = – 3.47，95% CI: – 5.94 – – 0.99). ConclusionHigher LDL-C level but lower HDL-C level may indicate a higher risk of AD in older adults.

Published in Zhongguo gonggong weisheng

ISSN: 1001-0580 (Print)
Publisher: Editorial Office of Chinese Journal of Public Health
Country of publisher: China
LCC subjects: Medicine: Public aspects of medicine
Website: https://www.zgggws.com/indexen.htm

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