PREVALENCE OF POLYMORPHIC VARIANTS OF GENES HLA SYSTEM IN HEALTHY DONORS OF KRASNODAR REGION

Abstract

Polymorphism studies major histocompatibility complex human (HLA-system) in the world, held from mid-60s, when serotyping methods revealed that in different populations are determined by different sets of options HLA-antigens. Genes of class II HLA-system determines a significant portion of the genetic predisposition to the development of the majority of diseases associated with the immune system. In the analysis of allelic polymorphism of the genes HLA-DQA1, HLA-DRB1, HLA-DRB1 found that among healthy donors Krasnodar in absolute terms more common alleles DQA1*0501, DQA1* 0201, DQB1* 0301, DQB1* 0601/8, DRB1 *01 DRB1* 15. Compare the population do not have significant differences and can be used as control groups in studies aimed at understanding the contribution of genes HLA II class for the development of diseases in the russian group. The results indicate the presence in the population of the Krasnodar territory is not only the «classical» alleles, but found only in Russia and in the region.

Keywords

• hla genes of the system
• population control
• alleles
• polymorphism
• antigens