Nature Communications (Apr 2021)
Deletion of Mfsd2b impairs thrombotic functions of platelets
- Madhuvanthi Chandrakanthan,
- Toan Quoc Nguyen,
- Zafrul Hasan,
- Sneha Muralidharan,
- Thiet Minh Vu,
- Aaron Wei Liang Li,
- Uyen Thanh Nha Le,
- Hoa Thi Thuy Ha,
- Sang-Ha Baik,
- Sock Hwee Tan,
- Juat Chin Foo,
- Markus R. Wenk,
- Amaury Cazenave-Gassiot,
- Federico Torta,
- Wei Yi Ong,
- Mark Yan Yee Chan,
- Long N. Nguyen
Affiliations
- Madhuvanthi Chandrakanthan
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Toan Quoc Nguyen
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Zafrul Hasan
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Sneha Muralidharan
- Department of Medicine, Yong Loo-Lin School of Medicine, National University of Singapore
- Thiet Minh Vu
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Aaron Wei Liang Li
- Department of Medicine, Yong Loo-Lin School of Medicine, National University of Singapore
- Uyen Thanh Nha Le
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Hoa Thi Thuy Ha
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Sang-Ha Baik
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Sock Hwee Tan
- Department of Medicine, Yong Loo-Lin School of Medicine, National University of Singapore
- Juat Chin Foo
- Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore
- Markus R. Wenk
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Amaury Cazenave-Gassiot
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Federico Torta
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- Wei Yi Ong
- Department of Anatomy, Yong Loo-Lin School of Medicine, National University of Singapore
- Mark Yan Yee Chan
- Department of Medicine, Yong Loo-Lin School of Medicine, National University of Singapore
- Long N. Nguyen
- Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-021-22642-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
The mechanisms by which platelets release sphingosine-1-phosphate (S1P) is not well characterized. Here the authors show that Mfsd2b is required for S1P release from both resting and activated platelets and that deletion of Mfsd2b impairs thrombotic functions of platelets.
