International Journal of General Medicine (Feb 2024)

Vulvar Hidradenoma Papilliferum

  • Wang L,
  • Chen G,
  • Jiang J,
  • Liu G,
  • Tuo YL,
  • Li X,
  • Zhang W

Journal volume & issue
Vol. Volume 17
pp. 663 – 667

Abstract

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Lixin Wang,1,* Gang Chen,1 Jingui Jiang,1 Guoyan Liu,2,* Ying-Lan Tuo,3 Xiaohong Li,4 Weishan Zhang5 1Department of Pathology, Jinhu County People’s Hospital, Huaian City, People’s Republic of China; 2Department of Gynecology, Jinhu County People’s Hospital, Huaian City, People’s Republic of China; 3Department of Pathology, Dazhou People’s Hospital, Dazhou City, People’s Republic of China; 4Department of Pathology, First People’s Hospital of Zigong City, Zigong City, People’s Republic of China; 5Department of Pathology, Suining People’s Hospital, Suining City, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jingui Jiang, Department of Pathology, Jinhu County People’s Hospital, Huaian City, Jiangsu Province, People’s Republic of China, Tel +86 18952332618, Fax +86 51786808703, Email [email protected]: This study examines the clinical and pathological characteristics, immune profile, histological occurrence, diagnosis, and differential diagnosis of vulvar hidradenoma papilliferum.Methods: An analysis was conducted on clinical data, histological patterns, and immunohistochemical findings from 45 cases of vulvar hidradenoma papilliferum, and relevant published articles were reviewed. Simultaneously, high-risk HPV typing was performed on these 45 cases.Results: The 45 cases of vulvar hidradenoma papilliferum displayed tumor sizes ranging from 0.3 to 2.0 cm and were observed to be pink or red in appearance. Vacuolated cytoplasm, large abnormal nuclei, distinct nucleoli, and scattered eosinophilic luminal secretions were observed in the glands. Positive staining for CK7 and progesterone receptor (PR) with focal mammaglobin and GCDFP-15 expression was found through immunohistochemistry. CK20 staining was noted as negative.Conclusion: Hidradenoma papilliferum is a rare benign tumor that originates in secretory glands. The diagnosis of this condition is aided by gross and immunohistochemical results, and differentiation from other conditions is necessary.Keywords: differential diagnosis, immunohistochemical staining, vulvar hidradenoma papilliferum

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