The purpose of the present study was to examine the effectiveness of positivism training on the quality of life enhancement with regard to the Holy Qur’an and Islamic trainings among Sistan and Baluchestan education organization employees. The population of this research consisted of 300 employees that 50 of them were selected at random as sample and were placed into two groups (25 employees for experimental group and 25 ones for control group). The research method was semi-experimental. The experimental group received 8 weekly 90 minute session of positivism training emphasizing the Holy Qur’an and Islamic issues and the control group did not receive any treatment. All subjects were assessed by the quality of life (sf-36) questionnaire; before treatment and 3-month follow up stage. Data were analyzed with multivariate analysis of covariance (MANCOVA) and analysis of covariance (ANCOVA). The results showed that experimental group had enhancement in quality of life, in both post-test and follow up.